| 초록 |
Heparan sulfate (HS) chains interact with proteins including growth factors/chemokines or their receptors, and regulate angiogenesis, cancer metastasis, or inflammation. As heparin has structural similarity to HS, heparin can compete with HS for protein interaction. We have reported oral heparin derivatives exhibiting inhibitory effects on rheumatoid arthritis. O-desulfation and bile acid conjugation were applied for development of nonanticoagulant oral heparins, and therapeutic mechanism of the derivatives were studied. Recently, we reported that heparan sulfate analogues derived from heparin can block the internalization of exosomes into cells. The competitive effect with HS was dependent on the structural characteristics and treatment concentrations of heparinoids. Glycol-split low-molecular-weight heparin efficiently inhibited cellular uptake of exosomes and cell migration stimulated by A549-derived exosomes. |
