| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
생체활성 조직유도 고분자(의료용고분자부문위원회) |
| 제목 |
Synthesis, Characterization, and Medical Applications of Hyaluronic Acid Derivatives |
| 초록 |
Hyaluronic acid (HA) is a biodegradable, biocompatible, non-immunogenic and linear polysaccharide which has been widely used for various medical applications. On the basis of real-time bio-imaging of HA derivatives in the body using quantum dots (QDots), highly modified HA derivatives were applied for a long acting conjugation of biopharmaceuticals and slightly modified HA derivatives were applied for targeted drug delivery to the tissues with HA receptors, such as the liver and tumors. The half-life of erythropoietin (EPO) conjugated with 20K stealth HA was comparable to that of 40K PEGylated EPO. Intratumoral injection of anti-VEGF siRNA/PEI-HA complex with 24 mol% PEI content resulted in the effective inhibition of tumor growth by HA receptor mediated endocytosis to B16F1 tumor cells in C57BL/6 mice. Furthermore, the degradation controlled stealth HA was successfully applied for tissue engineering applications such as tissue augmentation and guided bone regeneration. |
| 저자 |
한세광 |
| 소속 |
포항공대 |
| 키워드 |
Hyaluronic acid; Medical Applications; Quantum Dots; siRNA; Tissue Engineering
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| E-Mail |
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