| 초록 |
Multifunctional biomaterials that provide physical, electrical, and structural cues to cells and tissues are highly desirable to mimic the characteristics of native tissues and efficiently modulate cellular behaviors. Herein, we synthesized conductive graphene hydrogels by mild chemical reduction of graphene oxide/polyacrylamide (GO/PAAm) composite hydrogels to obtain conductive hydrogels. The reduced hydrogel, r(GO/PAAm), exhibited muscle tissue-like stiffness with a Young's modulus of approximately 50 kPa and low electrochemical impedance. Also, we further micropatterned with femtosecond laser ablation (FLA). Material conductivity and surface micropatterns substantially promoted differentiation. Electrical stimulation of the myoblasts on the conductive hydrogels promoted their myogenesis. In conclusion, we successfully demonstrated that the r(GO/PAAm) may serve as an effective multifunctional biomaterial that can mimic native muscle tissues. |
