| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Cytotoxicity and potential applicability of polyethyleneimine-coated Eu2O3 and Dy2O3 nanoparticles as X-ray CT contrast agents |
| 초록 |
Rare-earth metal oxide nanoparticles considered promising contrast agents for X-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability of polyethylenimine (PEI)-coated Eu2O3 and Dy2O3 nanoparticles (NPs) for CT X-ray attenuation. Morphology and other physicochemical properties of prepared samples were systematically investigated using a range of characterization tools. Preliminary cytotoxicity experiments with L-929 fibroblastic cells suggested that both samples have no significant toxicity at concentrations below 50 μg/ml. Clinical CT analysis shows that PEI@ Eu2O3 NPs exhibit higher X-ray attenuation efficiency (~ 8 HU/mM) compared to PEI@Dy2O3 NPs (~ 5 HU/mM). |
| 저자 |
강문성1, 이석현1, 이지은1, 김춘태1, Timur Sh. Atabaev2, 한동욱1
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| 소속 |
1부산대, 2Nazarbayev Univ. |
| 키워드 |
Rare-earth metal oxide nanoparticles; X-ray CT Contrast Agents; Cytotoxicity;
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| E-Mail |
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