| 초록 |
Blood transfusion-related adverse reactions have been reported to be caused by leukocytes in blood products. In this study, poly(buthylene terephthalate) melt-blown non-woven (PBT-NW) was treated by a surface-modification method using hydroxyapatite (HA) for removal of leukocytes from blood components. The PBT-NW surface was covered with a thin layer of HA produced by immersing the polymer surface in an aqueous solution containing high concentrations of PO43- and Ca2+ after graft-polymerization of acrylic acid, which provided the nucleus for the HA crystallization. The surface characterization was analyzed by using water contact angles, ATR-FT-IR and ESCA. HA-deposited PBT-NW (PBT-HA), when tested for removing leukocytes from a unit of red blood cell concentrates (RBCs), showed 98.5% of leukocyte removal rate and 99.5% of erythrocyte recovery rate, suggesting that HA-deposited PBT-NW would be a very promising blood filter for selective removal of leukocytes. |
