| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and Characterization of Polymeric Micelles with pH-Sensitive Surface Charge for Enhanced Theranostics |
| 초록 |
Polymeric micelles as carriers for drugs and imaging agents have been investigated extensively in the past decades. Herein, we designed a nano-sized drug delivery system which has two advantages compared to conventional PEG-based systems. First, the surface of the micelle is neutral at physiological pH and positively charged at tumor pH, that will enhance the uptake of the nanoparticles by cells while reduce the interactions with red blood cell (RBC) during circulation in the blood vessel. Second, compared to PEG, the hydrophilic main chain is biodegradable and the excess hydroxyl group made it possible to be further functionalized by imaging agent and target ligand. |
| 저자 |
이의1, 이두성2
|
| 소속 |
1Sungkyunkwan Univ., 2성균관대 |
| 키워드 |
biomaterials; pH-responsive
|
| E-Mail |
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