| 초록 |
Glycol Chitosan (GC) is a naturally derived polymer and has been widely used as a biomaterial due to its biodegradability, biocompatibility and enhanced solubility in neutral water. Moreover, continuous urge for new biomaterial leads to synthesis of GC derivatives with additional surface functionalities for different biomedical applications. In this study, we focused on conjugation of GC with gallic acid (GA, 3,4,5-trihydroxybenzoic acid), which is a natural phenolic acid from plant. GA has antioxidant ability and antibacterial activity. We synthesized GA conjugated GC (GA-GC) via amide coupling reaction between GC and GA. The degree of conjugation was determined by 1H NMR. The successful synthesis of GA-GC was further confirmed by functional group peaks in ATR-FTIR spectrum. The antioxidant capacity of GA-GC was much higher than that of the GC examined by assay of DPPH (2,2-diphenyl-1-picrylhydrazyl). The self-healing property was evaluated using rheological property of the GA-GC. |
