| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Solid Dispersion Formulations of Pioglitazone HCl Using Rotary Evaporation for Improved Dissolution Rate. |
| 초록 |
Pioglitazone is a thiazolidinedion antidiabetic agent which decreases insulin resistance in the periphery and in the liver. Pioglitazone is insoluble in water and has a low dissolution rate. The objective of the current work was to improve aqueous solubility of pioglitazone by solid dispersion approach using Rotary evaporation technique. We prepared pioglitazone HCl solid dispersion using polymeric material i.e. HPMC and PVP. One of its most important characteristics is the high swellability, which has a significant effect on the release kinetics of an incorporated drug. PVP makes drug water-soluble. We analyzed surface of solid dispersed sample by scanning electron microscope(SEM) and X-ray diffraction(XRD) was used to analyze the crystallinity. Also the change of structure and crystallinity characteristic of solid dispersion tablet were analyzed by fourier-transform infrared spectroscopy(FT-IR). |
| 저자 |
심보라, 이원택, 정현기, 박현, 전성현, 송정은, 강길선
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| 소속 |
전북대 |
| 키워드 |
pioglitazone HCl; solid dispersion; rotary evaporation; dissolution; HPMC; PVP
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| E-Mail |
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