| 학회 | 한국화학공학회 |
| 학술대회 | 2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 | 25권 2호, p.1485 |
| 발표분야 | 생물화공 (Biochemical Engineering) |
| 제목 | Removal of Residual Solvents from Solvent-Induced Amorphous Paclitaxel by Alcohol Pretreatment |
| 초록 | Abstract The In this study, a drying method that can effectively remove residual solvents from chloroform-induced amorphous paclitaxel was developed. The simple rotary evaporation with alcohol (methanol or ethanol) pretreatment was sufficient to remove residual chloroform and alcohol concentrations below the ICH limits (60 ppm for chloroform, 3,000 ppm for methanol, and 5,000 ppm for ethanol). In addition, the SEM analysis and ultrasonic treatment showed that residual solvent removal is related to the porous structure of the sample due to the high vapor pressure of the chloroform-alcohol mixture and the hydrogen bonding between chloroform and alcohol. Acknowledgment This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Korean Ministry of Education, Science and Technology (Grant Number: 2018R1D1A3A03000683). |
| 저자 | 강회종, 김진현 |
| 소속 | 공주대 |
| 키워드 | 생물화학공학 |
| 원문파일 | 초록 보기 |
