| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Doubly-Responsive Polymersomes for Smart Insulin Delivery Vehicles under Physiological Conditions |
| 초록 |
Organoboronic acid-containing polymers and block copolymers have attracted recent attention because of their ability to recognized important natural diol compounds such as saccharides and nucleotides. We synthesized the new monosaccharide-responsive polymers comprised of random copolymers of styrene-boroxole and oligo(ethylene glycol)-functionalized styrene (OEG-St). The block copolymers self-assembled into glucose-responsive micelles and vesicles. Due to the presence of solubilizing groups surrounding the glucose-responsive boroxole units in the polymer backbone, the resulting copolymers showed glucose-responsive behavior at lower glucose concentration compared to the glucose level for the responsive behavior of PBOx homopolymer. Vesicles showed glucose-triggered disassembly under physiologically relevant pH conditions and glucose levels (10 ~ 20 mM). |
| 저자 |
정은선, 임소령, 김경택
|
| 소속 |
UNIST |
| 키워드 |
Boroxole; LCST; Insulin delivery
|
| E-Mail |
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