| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
Doubly Responsive Polymersomes for Smart Delivery Vehicles under Physiological Conditions |
| 초록 |
Organoboronic acid-containing polymers and block copolymers have attracted recent attention because of their ability to recognize important natural diol compounds such as saccharides under physiologically relevant conditions at neutral pH. Here we report the monosaccharide-responsive polymers comprised of random copolymers of styreneboroxole and oligo(ethylene glycol)-functionalized styrenes (OEG-STs). We show that homopolymers and copolymers of OEG-STs are thermally responsive by demonstrating that they possess the characteristic of tunable lower critical solution temperature (LCST) in water. By introducing the minimum number of monosaccharide-responsive styreneboroxole units onto the thermally responsive OEG-ST backbone consisting, we synthesized doubly amphiphilic block copolymers. It could be utilized as new delivery vehicles for cargo molecules such as insulin, due to their ability to function in complex in vivo environment. |
| 저자 |
정은선, 박치영, 김경택
|
| 소속 |
UNIST |
| 키워드 |
LCST; boronic acid; boroxole; monosaccharide
|
| E-Mail |
|
