| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.292 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Enhanced Absorption of Simvastatin after Oral Administration using a Self-Emulsifying Drug Delivery System |
| 초록 | Simvastatin, a poorly water soluble drug and widely used for the treatment of hypercholesterolimia, was incorporated into the self-emulsifying drug delivery system (SEDDS) to improve the absorption and enhance the bioavailability. The SEDDS was optimized by evaluating their ability to self-emulsifying when introduced to an simulated intestinal fluid (pH 6.8) and gentle agitation, and by determination of particle size of the resulting emulsion. Simvastatin is a lactone prodrug. As a lactone prodrug administered orally, it hydroyzes to simvastatin acid by liver enzyme. Simvastatin acid was systhesized and quantitative determination of simvastatin and simvastatin acid were quantitated by HPLC. The absorption profile from SEDDS which has different droplet size was investigated in SD rats. The self-emulsifying formulations of simvastatin with the smaller droplet size afforded many improvements in absolute oral absorption relative to previous data of simvastatin tablet formulation and the larger droplet size. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of simvastatin and potentially other poorly absorbed drugs. Acknowledgment: This work was supported by KMOHW (Grant No.; HMP-98-G-2-051-B). |
| 저자 | 윤복영1, 정상영*2, 강길선3, 이해방**, 조선행** |
| 소속 | 1전북대, 2*대화제약, 3**한국화학(연) |
| 키워드 | |
