| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Hypoxia-Sensitive Self-Immolative Dendrimer for Drug Delivery Application |
| 초록 |
Self-immolative dendrimer has well defined 3-D branched structure with designed for controlled release of various molecules. Self-immolative dendrimer undergo triggered degradation under specific condition and release small molecules, which attached at dendrimer tail end and dendrimer building block. Most solid tumor has hypoxic condition because it located far from blood vessels(150 um), which provides the conditions of low oxygen level and abnormal tumor tissue environment. Dendrimer has relatively small hydrodynamic volume so we expect to display advantage in accessing hypoxic region in solid tumor. In this study, we apply nitro group for hypoxia-sensitive trigger at dendrimer core and anticancer drug was modified at dendrimer tail end for drug delivery application. Nitro group undergo reduced by metabolic reduction at hypoxic condition, cascade reaction progressed by carbamate linkage and release anticancer drug which conjugated at the periphery of dendrimers. |
| 저자 |
정인재1, 이주형2, 안철희3
|
| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering |
| 키워드 |
dendrimer; cascade; drug delivery; self-immolative; hypoxia sensitive
|
| E-Mail |
|
