| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.341 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Development of self-microemulsifying drug delivery systems (SMEDDS) for local theraphy of BCNU |
| 초록 | We developed self-microemulsion (SME) system achieve to the good antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) for 9L gliosarcoma cells and to increase of penetration depth of BCNU in brain tissue. The SME system composed of tributylin, Cremophor RH 40, and Labrafil 1944 to have an effect on 9L gliosarcoma cells of further distance range than intact BCNU wafer. The particles size could be altered by varing the oil composition in SME system. In this work, we try to determine particle size according to constitution of components and antitumor activity for 9L gliosarcoma cells by each size using morphological observation. We analyzed droplet size of microemulsion into dynamic light scattering (DLS ). Also, antitumor activity for 9L gliosarcoma cells is observed the morphology of cells according to distance from treated wafer in petridish and changed exposure time of SME BCNU by particle size. In our study, we will investigated appropriate SME formulation for antitumor activity and use to tissue penetration test in in vivo. Acknowledgment: This work was supported by KMOCIE |
| 저자 | 채강수1, 김선화1, 정상영2, 김문석2, 조선행2, 강길선1, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | wafer; self-microemulsion system; 9L gliosarcoma cell; particle size |
