| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Sustained Release of Simvastatin from Surface-Immobilized Polymer Nanoparticles for Enhanced Osseointegration |
| 초록 |
Surface engineering with bioactive drugs has been widely utilized to promote the performance of medical devices. A recent trend has focused on the development of surface-releasing systems that enable to accelerate the osseointegration of dental implants. In particular,the surface immobilization of nanocontainers that can control the release of bioactive molecules has emerged as a promising technique. In this study,we develop a nanoparticle-immobilized titanium surface that can release simvastatin in a controlled manner.The simvastatin-loaded nanoparticles were prepared by self-assembly of 5β-cholanic acid-conjugated glycol chitosan in the presence of simvastatin. The successful immobilization of nanoparticles onto titanium surfaces was confirmed by FE-SEM and XPS. The release of simvastatin lasted for up to 20days. These results suggest that the nanoparticle immobilization technique can be tailored for the sustained release of various bioactive agents from the diverse medical devices. |
| 저자 |
제갈준호, 이상천, 최기현, 이홍재
|
| 소속 |
경희대 |
| 키워드 |
Nanoparticle; Simvastatin; Titanium; Release; Osseointegration
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| E-Mail |
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