| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Sustained Release of Simvastatin from Polymer Nanoparticle-Immobilized Surfaces for Enhanced Osteogenic Activity |
| 초록 |
Surface engineering with bioactive drugs has been utilized to promote the performance of medical devices. A recent trend has focused on the development of surface-releasing systems that enable to accelerate the osseointegration of dental implants. In particular, the surface immobilization of nanocontainers that can control the release of bioactive molecules has emerged as a promising technique. In this study, we develop a nanoparticle-immobilized titanium surface that can release simvastatin in a controlled manner. The simvastatin-loaded nanoparticles were prepared by self-assembly of 5-cholanic acid-conjugated glycol chitosan in the presence of simvastatin. The successful immobilization of nanoparticles onto titanium surfaces was confirmed by FE-SEM and XPS. The release of simvastatin lasted for up to 20 days. These results suggest that the nanoparticle immobilization technique can be tailored for the sustained release of various bioactive agents from the diverse medical devices. |
| 저자 |
제갈준호, 김다은, 이홍재, 이상천
|
| 소속 |
경희대 |
| 키워드 |
simvastatin; polymer nanoparticle; surface engineering
|
| E-Mail |
|
