| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Biosynthesis and Characterization of Growth Factor Receptor Binding Polypeptides for Advanced Drug Delivery |
| 초록 |
A specific ligand binds to a growth factor receptor (GFR) in the cell membrane, which could trigger a wide variety of intracellular signaling. In this study, GFR binding fusion polypeptides composed of thermally responsive elastin-based polypeptides (EBPs) and GFR targeting peptides were genetically engineered, expressed, purified and their physicochemical properties were characterized. The EBPs were introduced as non-chromatographic purification tags while the GFR targeting peptides being presented for GFR targeted drug delivery. Especially, introduction of a series of EBP diblock copolymers to the GFR targeting peptides resulted in formation of temperature-triggered core-shell micellar structures with multivalent GFR binding peptides under physiological conditions, which could largely enhance their binding affinity to GFRs. This work suggests that the thermally responsive GFR binding polypeptides would open a new avenue for advanced drug delivery system. |
| 저자 |
강민정1, 이재상2, 임동우3
|
| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus |
| 키워드 |
Thermal responsiveness; Elastin-Based Polypeptides; Targeting polypeptides; Fusion proteins; Drug delivery systems
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| E-Mail |
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