| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Improvement of Dissolution Rate as Ratio of Atorvastatin Solid Dispersion Using Water Soluble Polymers |
| 초록 |
Atorvastatin is used for the treatment of dyslipidemia and the prevent of cardiovascular disease. It has about 14% of bioavailability. The aim of this study is to improve the dissolution rate of atorvastatin calcium by solid dispersion. Solid dispersion was formulated by using the water soluble polymer such as PVP, and Eudragit E PO. The crystallinity of atorvastatin calcium was measured using X-ray diffraction. Fourier-transform infrared spectroscopy was used to analyze the change in chemical structure of the atorvastatin and mixtures. SEM images indicated morphology of drug, polymer, and prepared solid dispersion. The in vitro test was implemented to confirm characteristic of dissolution of atorvastatin solid dispersion in simulated intestinal fluid (pH 6.8). This study showed improvement of dissolution rate of atorvastatin by water soluble polymer and spray drying. This research was supported by Polymer BIN Fusion Research Team. |
| 저자 |
이현구, 오승창, 이정환, 김하늘, 김혜윤, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Solid dispersion; Dissolution; Atorvastatin; Spray dryer
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| E-Mail |
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