| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characteristics and Controlled Dissolution of Celecoxib Solid Dispersion |
| 초록 |
We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using spray dryer to improve solubility of celecoxib. We used PVP K-30, eudragit EPO as a water soluble carrier for the solid dispersion, and SLS as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), x-ray diffraction (XRD) and fourier-transform infrared spectroscopy (FT-IR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The in vitro test was implemented to confirm characteristic of dissolution of celecoxib solid dispersion in gastric juice (pH 1.2). This studies showed improvement of dissolution rate of celecoxib by water soluble polymer and spray drying. This research was supported by MIFAFF (112007-05-1-SB010) and the MEST (2012M3A9C6050203). |
| 저자 |
박진영, 전대연, 장지은, 김영래, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Celecoxib; PVP K-30; Eudragit EPO; Solid dispersion; SEM; DSC; XRD; Spray-drying
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| E-Mail |
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