| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Electrospun Nanofiber-Mediated delivery of proliferation modulating Growth Factor for the treatment of Myocardial Infarction |
| 초록 |
Myocardial infarction (MI) remains the commonest cause of cardiac-related death throughout the world. In this study, we are presenting nanofiber mediated gene delivery for myocardial infarction. Branched polyethylenimine cross-linked via disulfide bonds (ssPEI) complexed with vascular endothelial growth factor (VEGF) were immobilized on the electrospun polycaprolactone (PCL)/ polyethylenimine (PEI) nanofibers for the local expression of VEGF angiogenic factor. Our results demonstrated that the delivery of therapeutic genes from biodegradable nanoparticles immobilized on the nanofiber represented minimal cytotoxicity to NIH/3T3 fibroblast cells and H9C2 myoblasts than branched PEI 25kDa did. According to luciferase assay, RT-PCR, this vector showed high transgene expression efficiency to reporter gene and VEGF gene. In vivo therapeutic efficacy with VEGF-embedded nanofiber will be evaluated for the treatment of myocardial infarction |
| 저자 |
차혜련, 박인규
|
| 소속 |
전남대 |
| 키워드 |
gene delivery; vascular endothelial growth factor; Myocardial infarction
|
| E-Mail |
|
