| 초록 |
Human adipose tissue-derived stem cells (hADSCs) have beenused as a representative therapeutic agent for tissue regeneration. However, conventional hADSC delivery systems have limitations, such as low celldensity, secreted cytokine levels, and cell viability. In this study, we developed a3D-structured stem cell-laden system for over-dense delivery of cells intosevere wound sites. Our system includes a hydrophobic surface and cavities thatcan enhance the efficiency of cell delivery to the wound site. In particular,the cavities in the system facilitate hADSC spheroid formation, increasingtherapeutic growth factor expression compared with two-dimensionally culturedcells. Our hADSC spheroid-loaded patch exhibited remarkably improved celllocalization at the wound site and dramatic therapeutic efficacy. The hADSC spheroiddelivery system focused on cell delivery, and stem cell homing effect at thewound site showed a significantly enhanced wound healing effect. |
