| 초록 |
Stereocomplex crystal of polylactide (sc-PLA) can be formed by stereocomplexation between poly(D-lactide) and poly(L-lactide) enantiomers. Generally, sc-PLA has improved thermal and mechanical properties. Conventional methods for stereocomplexation include solution casting, melt blending, and supercritical fluid technology. However, current methods have many limitations such as low solubility and processability, small yield, high cost and time consuming. To overcome these limitations, novel method has been developed using emulsion solvent diffusion process for stereocomplexation of polylactide. This simple method can form sc-PLA with high yield and speed compared to the conventional methods. Furthermore, 5-Fluorouracil of cancer drug can be encapsulated into sc-PLA particle during stereocomplexation using the novel method. This study suggests a novel strategy for fabrication of drug-eluting scaffold of sc-PLA with high mechanical and thermal properties. |
