| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Near Infra-Red-Light Responsive Cartilage Acellularized Matrix Derived Injectable Hydrogels for Stimuli-Responsive Drug Release Applications. |
| 초록 |
In this work, we developed doxorubicin (DOX)-loaded novel type of NIR-responsive and injectable hydrogels derived from cartilage acellularized matrix (CAM), by using a coumarin-based and water-soluble cross-linker. The hydrogels were developed by mixing norbornene (Nb) functionalized CAM with various feed ratios of the cross-linker. The drug release experiments demonstrated a rapid and sustained release of the DOX from the hydrogels upon NIR exposure. Interestingly, it was also observed that irradiation time was an important parameter to control the DOX release rate from the hydrogels. The empty-hydrogels were non-toxic to tested cell-lines and doxorubicin (DOX)-loaded hydrogels induced anti-cancer activity in cancer cells, after NIR treatment. Therefore, the NIR photo-responsive injectable hydrogels could be promising candidates for stimuli-responsive drug delivery applications. |
| 저자 |
주수빈, Muhammad Gulfam, 박찬, 임권택
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| 소속 |
부경대 |
| 키워드 |
NIR; Coumarin; cartilage acellularized matrix; injectable hydrogel
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| E-Mail |
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