| 학회 | 한국재료학회 |
| 학술대회 | 2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 | 22권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | Gold nanoparticle incorporated surface bioaffinity sensing platforms for biomedical and environmental applications |
| 초록 | During the last decade, numerous efforts have been made on developing highly sensitive and selective bioaffinity sensing platform in conjunction with gold nanoparticles for a wide range of biological and environmental applications. In this talk, we will highlight recent developments made on the combined use of biofunctionalized gold nanoparticles and surface sandwich complex formation to improve the sensitivity and selectivity of bioaffinity sensing platforms for medical diagnostics and environmental applications. The first part of my talk includes the development of new surface-based sandwich assay in conjunction with antibody conjugated nanoparticles (NPs) for the detection of various disease biomarker proteins including B-type natriuretic peptide[1], alpha-1-trypsin, tau 381 in serum and plasma[2-3]. The second part of my talk presents the combined use of biofunctionalized nanoaprticles and site selective enzyme reactions for creating highly sensitive and selective electrochemical bioaffinity sensing platforms which can be usefully employed for avian influenza virus (AIV) proteins [4], beta-amyloid peptide, in addition to phenolic compounds [5]. Lastly we will discuss future aspects and challenges of nanoparticle incorporated biosensing platforms. References [1] H. R. Jang, A. W. Wark, S. H. Baek, B. H. Chung, H. J. Lee*, Anal. Chem., 2014, 86, 814-819 [2] S. Kim, A. W. Wark, H. J. Lee*, Anal. Chem., 2016, 88, 7793-7799. [3] S. Kim, H. J. Lee*, Anal. Chem., 2015, 87, 7235–7240. [4] MD. N. Karim, J. E. Lee, H. J. Lee*, Biosens. Bioelectron., 2014, 61, 147-151. [5] D. F. Sharmin, S. Kim, H. J. Lee*, Biosens. Bioelectron., 2015, 72, 355-361. |
| 저자 | 이혜진 |
| 소속 | 경북대 |
| 키워드 | <P>Gold nanoparticles; bioaffinity sensors; disease biomarkers; suface sandwich assays</P> |
