| 초록 |
Coating and grafting have been widely used in blood contact medical device as methods to improve hemocompatibility. Although they have been applied extensively, they present limitations such as adhesive stability problem for coating and complicated process for grafting. In this study, blends of hydrophilic additives with oligomeric backbone was used to improve the surface properties of PVC. Several types of oligomeric polyurethane with sulfobetaine were used as additives. In the first study, polyurethanes with zwitterion side chains were synthesized and with metal ions achieving both anti-thrombotic and antibacterial properties. In the second study, fluorinated groups were combined with zwitterion side chains. The fluorinated groups induced surface segregation of polyurethane additives and enhanced anti-thrombotic property by the synergistic effect of fluorinated and zwitterion groups. These studies encouraged current ongoing study based on architectural stucture. |
