| 학회 |
한국화학공학회 |
| 학술대회 |
2017년 봄 (04/26 ~ 04/28, ICC 제주) |
| 권호 |
23권 1호, p.893 |
| 발표분야 |
재료 |
| 제목 |
Extra-large pore mesoporous silica nanoparticles for in vivo M2 macrophage polarization by IL-4 delivery |
| 초록 |
Over the past decade, mesoporous silica nanoparticles (MSNs) have been researched for systemic drug delivery. The small molecule delivery via MSNs has been successfully performed by high surface area and pore volume. However, the encapsulation of large therapeutic biomolecules still remained limitation due to 3 nm small pore size of the MSNs. In this study, we demonstrate the synthesis of mesoporous silica nanoparticles with extra-large pores (XL-MSNs) and their application to in vivo cytokine delivery for macrophage polarization. XL-MSNs with 30 nm extra-large pores were synthesized using additive organic solvent to construct extra-large pore structure. XL-MSNs showed significantly higher loading capacity for the various model proteins. XL-MSNs were used to deliver IL-4 to macrophages and polarize them to anti-inflammatory M2 macrophages in vivo. XL-MSNs induced low level of cytotoxicity in BMDCs and in mice i.v. injection with XL-MSNs. Finally, we demonstrated that IL-4-loaded XL-MSNs successfully led M2 macrophage polarization in vivo, suggesting clinical potential of XL-MSNs for immunomodulation via targeted delivery of various functional cytokines. |
| 저자 |
차봉근1, 권도형2, 조유리2, 민지연2, 박은별2, 강석조2, 김재윤1
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| 소속 |
1성균관대, 2KAIST |
| 키워드 |
화공소재 전반 |
| E-Mail |
|
| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
