| 초록 |
In biomaterials research, controlling cellular interactions between cell and polymer is one of the most critical factor in the design of synthetic extracellular matrix, and cellular adhesion peptides present in polymer hydrogels play a role in regulating multiple aspects of cell phenotype, including stem cells. In this study, we hypothesized that controlling the spacer arm length of adhesion peptides could regulate the D1 stem cell differentiation cultured within alginate-based hydrogels. Osteogenic and adipogenic differentiation of D1 stem cells was promoted by increasing the spacer arm length of RGD peptides, as cells could easily access to the RGD peptides. However, chondrogenic differentiation of D1 stem cells was independent of the spacer arm length of RGD peptides. This approach to controlling the spacer arm length of adhesion peptides in biomimetic hydrogels could find useful applications in tissue engineering. |
