| 학회 | 한국화학공학회 |
| 학술대회 | 2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 | 22권 2호, p.1850 |
| 발표분야 | 생물화공 |
| 제목 | Supperparamagnetic iron oxide nanoparticels for biomedical application |
| 초록 | In this study, we prepared iron oxide nanoparticles (IONs) capping oleic acid by thermal decomposition method. The synthesized IONs were coated with the grafted polymers which are biocompatible and hydrophilic. The backbone of polymer is polysuccinimide (PSI), a polymer biocompatible. Multifunctional polymers were grafted on PSI, including hydrophilic O-(2-aminoethyl) polyethylene glycol (PEG) and hydrophobic octadecylamine (C18) for amphiphilic structure, pH-sensitive - hydrazine hydrate to release drugs, and biotin to interacts with receptors on cancer cell surfaces. The coated IONs were applied for MRI contrast agents and target drug delivery. The structure of the polymers was confirmed by 1H NMR. The size and distribution size of nanoparticles were defined by TEM and DLS. Magnetism property of IONs was measured by SQUID and Relaxometry measurement appreciated the ability of nanoparticles for MRI contrast agent. Effective toxicity cells were analyzed by MTT assay in MCF7 cells. Keywords: iron oxide nanoparticles (IONs), biomedical applications, super-paramagnetic, amphiphilic polymer |
| 저자 | Nguyen Minh Phuong, 김덕준 |
| 소속 | 성균관대 |
| 키워드 | 의약생물공학; 바이오칩/나노바이오공학; 기능성바이오/융합소재공학 |
| 원문파일 | 초록 보기 |
