| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
LC-MS/MS based targeted metabolomics analysis of bile acids from malignant and benign gallbladder cancer patients |
| 초록 |
Gallbladder cancers can be difficult to detect because they are located deep inside the body and sometimes they may be no symptoms at all. To find the association between malignant gallbladder cancer and bile acids, this study analyzed the bile acid concentration and composition in bile of malignant and benign gallbladder cancer patients. We quantified major unconjugated bile acids in bile (cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid and ursodeoxycholic acid) as well as their glycine- and taurine-conjugates by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Malignant and benign gallbladder cancer bile could be distinguished by quantification of their major bile acids. Therefore, this diagnostics could be valuable for detecting a malignant gallbladder cancer. |
| 저자 |
송원석1, 박한규2, 황철환2, 김윤곤2, 김병기1
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| 소속 |
1서울대, 2숭실대 |
| 키워드 |
bile acid; gallbladder cancer; SRM; LC-MS/MS
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| E-Mail |
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