| 초록 |
Computed tomography (CT) is one of the diagnostic devices however it is difficult to diagnose disease in soft tissues. So, CT contrasts are important to improve CT contrast image in soft tissues. Endoscopic retrograde cholangiopancreatography (ERCP) is usually performed for bile duct imaging. But ERCP is invasive diagnosis method. So, we develop liver targetable CT contrast agent (LTC). LTC can treat easily through I.V. inject. LTC is composed with iodine-based material, liver targeting moiety, solubility increasing regions. Targeting moiety can interact with receptor in liver. In vitro, we have confirmed specific interaction and uptake in liver cells and non-liver cells. In vivo, we have confirmed the biodistribution of body. Also, we measure iodine content in bile juice of LTC treat group against the commercial contrast agent (CCA) treat group. We have confirmed contrast effect in the bile duct. We have confirmed elimination of LTC by detecting LTC in urine and feces. |
