| 초록 |
The amphiphilic polymers poly(Vinyl pyrrolidone-co-Methyl methacrylate) (P(VP-co-MMA)) showing LCST behavior having different VP/MMA contents (95:5, 94:6, 92.5:7.5 (mol/mol)) were produced by a free radical polymerization. LCST behavior was confirmed by measuring the O.D (Optical density) value due to temperature change from 20 ℃ to 50 ℃ using a UV-Vis spectrophotometer. The surface tension with the hydrophilicity and hydrophobicity ratio of the copolymer was measured through a ring method. P(VP-co-MMA) micelle was prepared using a swelling method. The sphere of micelles was analyzed by transmission electron microscopy (TEM), the average and standard deviation of the micelle diameter were measured using an image analysis program. Release with time lapse at 23.5, 37, 45 ℃ and the critical micelle concentration was evaluated by fluorescence spectroscopy using nile red as a probe. |
