| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Nitric Oxide Releasing Artificial Membranes Anchored on Titanium for Selective Control of Vascular Cells |
| 초록 |
Surface-tethered lipid bilayer (TLB) membranes with incorporated lipophilic NO donor (10-nitrooleate) into the bilayer coated on titanium to achieve controlled release of NO. The NO-releasing TLB membranes are prepared via two steps, Tethering of phospholipids then fusion of 10-nitrooleate-containing liposomes. Protein adsorption test with albumin and fibrinogen shows significantly diminished adsorption rates on the TLB-coated titanium than that on bare titanium. TLB membranes with different amounts of incorporated 10-nitrooleate (15, 25 and 30%) release NO at similar patterns up to 48 h, although the half-dose release rates are evidently different (3.3, 2.6 and 1.8 h). In vitro study reveals the cellular species-dependent result demonstrating the selective effects of released NO and TLB membrane that promotes endothelial cells but suppresses smooth muscle cells. The results open up a door for the potential use of NO-releasing TLB coating for a wide range of biomedical devices. |
| 저자 |
마무드1, 한동근2, 정윤기3
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| 소속 |
1한국과학기술(연), 2차의과학대, 3KIST |
| 키워드 |
tethered lipid bilayer; lipid bilayer membrane; nitric oxide; nitrated lipids; nitrooleate; and titanium.
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| E-Mail |
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