| 초록 |
Owing to the outstanding progress in the nano-medicine field, a variety of nano-carriers have been designed to specifically deliver the cargo to the target site, in response to the specific stimuli. Photo-thermal therapy (PTT) is a light based molecular targeted cancer therapy, which uses electromagnetic radiations most often in infrared wavelength for the treatment of cancer. In this study, we are proposing CD44 targeted IR-780 loaded HA-C18 micelles, which can produce ablation temperature upon laser irradiation. Furthermore, we designed a stimuli responsive, cationic charged micelle as a drug carrier for treatment of peritoneal metastasis. Taken together, design of nano carriers responding to exogenous or endogenous stimuli represents an attractive option for triggering the on-demand drug release and thereby enhancing the therapeutic efficacy. |
