| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 봄 (04/24 ~ 04/26, 광주 김대중컨벤션센터) |
| 권호 |
19권 1호, p.59 |
| 발표분야 |
고분자 |
| 제목 |
Phase Transition Behavior of Novel pH and Thermal-Sensitive Poly(N-isopropyl acrylamide-co-Acrylic acid)-graft-Polyaspartate coated Magnetic Nanoparticles |
| 초록 |
A series of pH- and thermo-sensitive poly(N-isopropyl acrylamide-co-acrylic acid) were synthesized by radical polymerization and grafted on polysuccinimide backbones. The polysuccinimide derivatives synthesized were coated on iron oxide magnetic nanoparticles for potential application in drug delivery systems with hyperthermia and chemotherapy. Those activities were based on core-shell shaped nano-aggregates in association with their inherent magnetic, pH- and thermal- properties. The structure of polymer-shell was confirmed by FT-IR and 1H-NMR spectroscopies and SEM. The phase transition was characterized by UV-Vis, light transmittance measurements, ad the particle size and its distribution at varying pH and temperature by ELS measurement. This novel drug delivery system is very promising in multifunctional therapy. |
| 저자 |
Tran Thi Thuy Van, 김덕준
|
| 소속 |
성균관대 |
| 키워드 |
drug delivery; hyperthermia; chemotherapy
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
