| 초록 |
A combination with chemotherapy and thermotherapy has been regarded as a promising technique for enhanced cancer therapy since it provides higher therapeutic efficacy then respective monotherapies. One of them is nanocarrier such as gold or magnetic nanoparticles. Although they have powerful advantages such as therapy and imaging, these still display some drawbacks including rapid clearance from a bloodstream with over accumulation in non-target organs, which prevent long-term therapy. In this context, for efficient long-term therapy, localized delivery to the solid tumor is a good strategy because it ensures therapeutic drug levels and adequate heat at the tumor site for extended periods of time. Here, we designed a new implantable structure providing reproducible plasmonic heating for photo-thermotherapy (PTT) and controllable drug release under NIR irradiation because it has a high absorption in NIR ranges. Also, feasible drug release control as well as PTT were achieved. In addition, it was successfully applied to stent for tumor cell apoptosis, which was confirmed in vivo. The new system propose dual therapeutic biomaterials that perform both controllable chemotherapy and PTT. |
