| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Reactive Oxygen Species Responsive Pheophorbide A-Glycol chitosan Nanoparticles for Photodynamic Cancer Therapy |
| 초록 |
We have designed amphiphilic reactive oxygen species (ROS) responsive nano-carrier for photodynamic therapy (PDT) by conjugating glycol chitosan and pheophorbide A with ROS responsive thioketal linker (GC-TK-PheoA). In aqueous solution, the amphiphilic GC-TK-PheoA bioconjugates self-aggregated to form core-shell structured nanoparticles through the hydrophobic interaction of PheoA. The resulting GC-TK-PheoA nanoparticles possess good colloidal stability. The photoactivity of GC-TK-PheoA nanoparticles was greatly suppressed in an aqueous environment by the self-quenching effect, which enabled the GC-TK-PheoA nanoparticles to remain photo-inactive and in a quenched state. However, the nanoparticular structure instantaneously dissociated in the presence of ROS, causing an efficient dequenching process. These results suggest that GC-TK-PheoA nanoparticles have good potential as a smart PDT nanoparticular system for anti-cancer therapy. |
| 저자 |
이지영1, Uthaman Saji1, 김유경1, 박인규2, 허강무1
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| 소속 |
1충남대, 2전남대 |
| 키워드 |
Drug delivery systems; Photodynamic therapy; Pheophorbide A; Glycol chitosan; Reactive oxygen species; Thioketal linkage
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| E-Mail |
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