| 초록 |
Tramadol-HCl (TH)-loaded polyoxalate (POX) microspheres were prepared by four different solvent compositions such as W1/O/W2, O1/O2/W, O/W, and O1/O2. We investigated the effect of POX molecular weight and the presence of hydrogen peroxide on the release behaviors of TH from POX and PLGA microsphere. The properties of TH-encapsulated POX microspheres were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and differential scanning calorimeter (DSC). We found the formation of uniform size distribution of the microsphere, regardless of the solvent compositions investigated, but lower drug encapsulating efficiency were found in the microspheres prepared from W1/O/W2, O1/O2/W, and O/W solvent compositions. Only the POX microsphere prepared from O1/O2 method showed reasonable drug encapsulating efficiency. POX microspheres showed highly sensitive H2O2-responsive drug release profile. This work was supported by the Brain Korea 21 PLUS Project, NRF. |
