| 초록 |
The purpose of this work was to develop micro-emulsion that could be safely used to promote transdermal delivery of Erythromycin (EM). EM is a hydrophobic drug widely used to treat infections. The prepared EM emulsion showed solvent content by moisture meter with alcohol-based EM gel, Eryacne. The viscosity measured and stability carried out. To evaluate EM skin penetration, Franz cell experiment is performed. EM emulsion contained about 30 % lower than Eryacne solvent content. The viscosity decreases than Eryacne. EM emulsion showed good stability after storage at 25 ℃ and 37 ℃ for 1 week, but Eryacne was precipitated at 37 ℃. The release amount from EM emulsion at 50 mg spread was higher than that at 150 mg, and released above 12 % for 1 day. In this work, we confirmed that micro-emulsified EM which could result in an improvement of stability of the solubilised hydrophobic EM in aqueous media. |
