| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Design of Transferrine-Conjugated Nanoparticles forCancer Targeting |
| 초록 |
To develop highly water-soluble and less toxic paclitaxel analogues, we designed and synthesized polymeric drug of paclitaxel(PX), polyethylene glycol(PEG) transferrin(TF) (TFPXPEG). The TFPXPEG was synthesized by reaction of PXPEG copolymer and TF. TFPXPEG was prepared by chemical reaction PXPEG and TF for targeted drug delivery system. The structure was investigated by FT-IR and ¹H-NMR, particle formation was confirmed to become by TEM and ELS-8000. The polymeric drug provides an alternative approach for formulation of poorly soluble drugs. TFPXPEG polymeric drugs showed comparable cytotoxicity as paclitaxel in KB cell and HepG2 cells. It was carried out cytotoxicity and anticancer activate experiment. Furthermore, these findings suggest that the combination of targeted drug carrier for cancer therapy. |
| 저자 |
손동희, 남정표, 박준규, 김원석, 최창용, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
Transferrine; PEG; Paclitaxel; cancer tageting
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| E-Mail |
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