| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Triple Stimuli-responsive Triblock Nanoparticle Micelles Based on Linear-Cyclic Polymer for Theranostic Delivery |
| 초록 |
We prepared a series of triblock poly(N-isopropylacrylamide)30-block-cyclic poly(L-lysine)n-block- poly(N-isopropylacrylamide)30 (p(NIPAM)30-b-Cyclic p(L-LYS)n- p(NIPAM)30) (n=10.20 and 30) polymer bio-conjugates via combination of reversible addition fragmentation chain transfer, Click reaction and ring opening polymerization of α-amino acid N-carboxyanhydrides. All the triblock polymer forms spherical micelles in aqueous solution and thus provides enough space for accommodate the potent anticancer drug Doxorubicin (Dox). Moreover, polymer micelles exhibited excellent drug loading capacity and drug loading efficiency, also in vitro drug release profile demonstrated that the maximum release of Dox was happened in pH 5.0 at 42 oC and in presence of glutathione (GSH) intracellular mimic environment. The results of triple stimuli responsive system expecting to be nice for the further studies in anticancer therapy. |
| 저자 |
RIMESH AUGUSTINE1, Saji Uthaman2, 박인규2, 김일3
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| 소속 |
1Pusan National Univ., 2전남대, 3부산대 |
| 키워드 |
Triple stimuli-responsive; biopolymers; drug delivery
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| E-Mail |
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