| 초록 |
Drug resistance of lung cancer causes the challenges in the development of new therapeutic agents, as well as the failure of chemotherapy. Various bio-inspired hydrogels have been utilized to create engineered 3D tumor microenvironments to forecast the effectiveness of anti-cancer drugs. Herein, we report a new type of engineered 3D tumor microenvironments to explore the drug resistance of lung carcinoma cells. We created engineered 3D lung carcinoma models by encapsulating drug-resistant human lung cancer cells into the interpenetrating network hydrogels composed of gelatin and poly (ethylene glycol). Utilizing advanced tumor models, we revealed the drug response and the resistance mechanisms of lung cancer cells against clinical anti-cancer agents in the 3D microenvironment. In conclusion, our hydrogels can serve as a promising platform to study basic cancer biology and screening of therapeutic agents for cancer treatment overwhelming drug resistance. |
