| 초록 |
API investigated was an intermediate for synthesizing the group of carbapenem antibiotics. By varying supersaturation level in batch cooling crystallization, polymorphic forms, Form II and Form III, were selectively crystallized. Transformation of API polymorph from FormI to FormIII during the crystallization was monitored by using in-situ measurement of ultrasonic velocity. Cooling crystallization using methyl ethyl ketone as a solvent was carried out. The polymorphs were identified with X-ray powder diffraction analysis. Induction time of FormI and Form III, width form growth of FormI, width for transformation from FormI to FormIII were measured in-line processing. |
