| 초록 |
Stress urinary incontinence (SUI), which is defined as the involuntary leakage of urine upon physical activity, sneezing or coughing, is considered a common and embarrassing problem among females. Various injectable bulking agents have been used in the treatment of stress urinary incontinence. However, injection volume decrement caused by particle migration and resorption in the body have been main problems for them. In this study, we prepared pDNA (encoding for bFGF)/PEI-PEG complex-loaded polycaprolactone (PCL) particle/poly(DL-lactic-co- glycolic acid) (PLGA) mixture as an injectable bioactive bulking agent which can provide bulking effect and stimulate the defect tissues around urethra for the effective treatment of urinary incontinence. The release behaviour of the pDNA/PEI-PEG complex from the mixture, cytotoxicity/cell transfection efficiency by the pDNA complex released from the mixture, as well as the bFGF expression from the gene transfected cells were investigated. |
