| 학회 | 한국재료학회 |
| 학술대회 | 2013년 봄 (05/23 ~ 05/24, 여수 엠블호텔(THE MVL)) |
| 권호 | 19권 1호 |
| 발표분야 | B. 나노재료(Nanomaterials) |
| 제목 | Materials and Designs in Multifunctional, Injectable Optoelectronic Devices for Optogenetic Application |
| 초록 | The techniques of optogenentics provide unique opportunities for studying many topics of fundamental interest in neuroscience. Existing mechanisms for delivering light into the tissues of living animals impose, however, significant constraints on the types of experiments that are possible. In this talk, we describe the materials science of a class of implantable, multifunctional, microscale devices that incorporate wireless powering and control strategies, to allow less-invasive study of intact neural systems in naturally behaving animals. The enabled modes of use are impossible to realize using standard approaches that rely on rigid, long, glass fiber optics coupled to external, bulky light sources. Our systems exploit ultrathin, flexible substrates populated with microscale inorganic light emitting diodes (LEDs) together with electrophysiological and temperature sensors, all mounted on removable plastic needles that facilitate insertion into the tissue. Detailed experimental and theoretical studies of the operation, ranging from heat flow aspects to inflammation assessments and comparison to conventional devices, illustrate the unique features of this technology. We exploit the devices for light stimulation of catecholaminergic cell populations selectively expressing channelrhodopsin-2, in awake, ambulatory mice. The results suggest that the reported materials and device designs have promise not only in optogenetic applications but also in other areas of implantable diagnostics and therapeutics. T. Kim and J. McCall contributed equally to this work |
| 저자 | Tae-il Kim1, Jordan G. McCall2, Michael R. Bruchas3, John A. Rogers4 |
| 소속 | 1School of Chemical Engineering, 2Sungkyunkwan Univ. (SKKU), 3Suwon, 4Korea |
| 키워드 | flexible LED; Optogenetics |
