| 학회 | 한국화학공학회 |
| 학술대회 | 2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 | 22권 2호, p.1392 |
| 발표분야 | 고분자 |
| 제목 | Multifunctional Nanogel for Targeted Imaging, Delivery, and Therapy |
| 초록 | Nanogel, nano-sized (＜ several hundred nm) hydrogel, has intrinsic advantages as a delivery system for tumor sites due to 1) EPR effect based on its size and 2) excellent biocompatiblity 3) as well as long circulation upon i.v. injection based on its hydrogel state. In my lab, nanogel was prepared using Pluronic, FDA-approved and temperature sensitive polymeric surfactant simply by one-pot synthesis in aqueous phase. This Pluronic-based nanogel has advantages as a delivery carrier including easy and efficient loading of any water soluble (bio)macromolecules while maintaining their bioactivities as well as nanoparticles that can be suspended in aqueous environment. The surface of the nanogel can be modified to provide various functionalities for targeted delivery or imaging. Various surface modifications of Pluronic nanogel could expand the functionalities of the nanogel. Several examples of the applications of this nanogel will be demonstrated including targeted delivery to the tumor, brain, oral route, imaging of selective inflammation sites and multimodality, and therapy for tumor and diabetes. |
| 저자 | 태기융1, 최원일2, 김자영3, 이종현4, 김만세4 |
| 소속 | 1광주과학기술원, 2세라믹(연), 3한화, 4광주과기원 |
| 키워드 | 바이오고분자 |
| 원문파일 | 초록 보기 |
