| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Hepatocytic Differentiation of Adipose Stem Cells in Dual Growth Factor-Loaded Alginate/HA Hydrogel for Liver Tissue Engineering |
| 초록 |
Liver tissue engineering requires a suitable cell source, methodologies to assemble the cells within their niche microenvironments in a spatially defined manner, and vascularization of the construct in vivo for maintenance of hepatocyte viability and function. In this study, we developed an injectable alginate/hyaluronic acid (HA) hydrogel system for the controlled release of growth factors [basic fibroblast growth factor (bFGF) and/or hepatocyte growth factor (HGF)] and thus enhancing the differentiation of adipose stem cells (ASCs) into hepatocytes. The growth factors were continuously released from the hydrogels for more than 35 days. The dual growth factor-loaded alginate/HA hydrogel showed the enhanced hepatocytic differentiation of ASCs compared to the hydrogels with single growth factor loading or those without growth factor. |
| 저자 |
최소리1, 김태호1, 이재선2, 오세행3, 전대원2, 이진호1
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| 소속 |
1한남대, 2한양대, 3단국대 |
| 키워드 |
Alginate; Hyaluronic Acid; Hydrogel; Growth Factor; Liver Tissue Engineering
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| E-Mail |
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