| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Hyaluronic Acid-based Hydrogel (HA) Containing Mesenchymal Stem Cells (MSCs) for Treating Hypofunction of Salivary Gland (SG) after Radiation Therapy (RT) |
| 초록 |
All patients of head and neck cancer suffer from the hypofunction of SG after radiation therapy due to high radiation-susceptible acini which secrete saliva, mucin, and amylase. However, current medicine for the hypofunction(xerostomia) cannot treat the damaged acini. Here, we introduced MSCs to radiation-damaged SG(RDSG) for preventing the progress of the hypofunction. When isolated SG cells from RDSG were co-cultivated with MSCs, the SG cells showed similar expression of mucin and amylase compared to normal SG cells. 10µl HA(2wt%) was employed to enhance the staying duration of MSCs(6.7 x 105 cells) in SG of radiation-treated mice. Regeneration and functional recovery of RDSG were evaluated by histology and SPECT, respectively. After 6 and 12 weeks, MSCs+HA showed 2-fold increase of proliferation compared to MSCs only. Also, MSCs+HA accelerated recovery of intrinsic functions of SG. Thus, the MSCs+HA could be a superior candidate for prevention of damage and regeneration of RDSG. |
| 저자 |
최지숙1, 정은재1, 신지수2, 조하나1, 김수연1, 조승우2, 권성근1
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| 소속 |
1서울대, 2연세대 |
| 키워드 |
Hydrogel; mesenchymal stem cell; salivary gland; radiation-damage
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| E-Mail |
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