| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Development of apoptosis-inducing polypeptide by mitochondria-destabilzation |
| 초록 |
Cationic α-helical polypeptides have been exhibited high cell-penetrating ability and usually have been used as cell-penetrating peptides to deliver drugs or genes into the cell. Mitochondria play a key role in inducing apoptosis in the cell. In this background, we developed mitochondria destabilizing polypeptide (MDP) using cell-penetrating ability of cationic α-helical polypeptide. To endow mitochondria-destabilizing ability to the MDP for inducing apoptosis, lipophilic cation moiety was attached as pendants in the side chain of polypeptide. MDP showed high α-helical properties that is necessary for cell-penetrability and mitochondria-destabilizing ability. MDP also exhibited unprecedented high cytotoxicity and apoptotic signals in various cancer cell lines. MDP has a high potential to applicate in various researches of cancer therapy regarding with its unprecedented high mitochondria-destabilizing ability. |
| 저자 |
하종훈, 이대용, 김유천
|
| 소속 |
한국과학기술원 |
| 키워드 |
anticancer agent; polypeptide; mitochondria destabilizing peptide
|
| E-Mail |
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