| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
In vitro Osteogenic differentiation and Anti-microbial Efficacy of Dual Growth Factor/Antibiotic-loaded PCL/HA Microsphere-Hydrogel System |
| 초록 |
The needs for microspheres made of biodegradable polymers have gradually increased with the developments of bioactive delivery systems, tissue engineering, and regenerative medicine. In this study, we prepared a BMP-2-loaded polycaprolactone (PCL)/hyaluronic acid (HA) hybrid microspheres and vancomycin-loaded alginate hydrogel carrier system to be used as an injectable bone filler. This microsphere-hydrogel system showed the sustained release of both BMP-2 and vancomycin for more than one month. We evaluated the osteogenic differentiation potential and anti-microbial efficacy of this microsphere-hydrogel system. From the results, both BMP-2- and vancomycin-loaded group showed better osteogenic differentiation than the control group (w/o BMP-2 and vancomycin) and the group with single BMP-2 or vancomycin. The groups with vancomycin also showed the long-term antimicrobial efficacy. |
| 저자 |
장희윤1, 신준영1, 김세현1, 김민지2, 곽유진1, 이인수1, 오세행2, 이진호1
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| 소속 |
1한남대, 2단국대 |
| 키워드 |
Osteogenic differentiation; Growth factor; Antibiotic; Microsphere; Hydrogel
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| E-Mail |
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