| 초록 |
This work demonstrated the highly controlled drug release and its controlled burst release at initial release time for a long period of time with HA nanocomposites of silicified L3-PNIPAm gels for hard tissue therapy, in which the silicified L3 phase and its PNIPAm composite showed the 3-D disordered non-linear porous channels. The aim of this work is to explore a new potential property of capability of acting as a convenient reservoir for long-term controlled drug release for hard tissue. For this purpose, we introduced indomethacin (IMC) into the L3-PNIPAm gels integrated HA scaffold and subsequently demonstrated the in vitro drug release process by the step-wised temperature change. The silicified L3-PNIPAm/HA composites have been prepared, which allows the control of the burst release at the initial time with step-wised temperature. In vitro analysis carried out with prepared material showed the non-cytotoxic, and well growing on surface of the matrix. |
